Beilstein J. Nanotechnol.2018,9, 2516–2525, doi:10.3762/bjnano.9.234
groups in oligonucleotides. The Si–NH2 nanoparticles and Si–NH2·ODNnanocomplexes were characterized by transmission electron microscopy, atomic force microscopy and IR and electron spectroscopy. The size and zeta potential values of the prepared nanoparticles and nanocomplexes were evaluated
complexes were predominantly detected in the cellular nuclei. The Si–NH2·ODNnanocomplexes demonstrated a high antisense activity against the influenza A virus in a cell culture at a concentration that was lower than their 50% toxic concentration by three orders of magnitude.
Keywords: antiviral effect
; non-agglomerated silicon–organic nanoparticles; penetration; Si–NH2·ODNnanocomplexes; Introduction
The development of efficient and convenient systems for the delivery of nucleic-acid-based drugs into cells is an urgent task. The solution to this problem would allow for the use of these drugs in
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Figure 1:
(a) Evaluation of molar ratio of the amino groups in the nanoparticles to the phosphate groups, NH2...